Related Experiment Video

Updated: Feb 7, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

708

The pathogenesis and available prevention options in patients with diabetic thrombophilia

Jacek Kwiatkowski1, Jowita Halupczok-Żyła2, Marek Bolanowski2

  • 1Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|August 1, 2018
PubMed

Insights

Diabetes mellitus (DM) causes acquired thrombophilia due to complex mechanisms affecting blood clotting. This increases cardiovascular risks and may alter medication effectiveness, necessitating awareness for better patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Endocrinology

Background:

  • Diabetes mellitus (DM) is a significant health concern associated with elevated cardiovascular and thrombotic risks.
  • Diabetic thrombophilia, characterized by coagulation-fibrinolysis imbalance, is a key complication of DM.
  • Multiple factors contribute to hypercoagulability in diabetes, including endothelial dysfunction, platelet alterations, and clot structure changes.

Purpose of the Study:

  • To elucidate the mechanisms underlying diabetic thrombophilia.
  • To investigate the impact of DM on the efficacy of antithrombotic therapies.
  • To highlight the importance of recognizing thrombotic risks in diabetic patients.

Main Methods:

  • Review of existing literature on diabetes, coagulation, fibrinolysis, and thrombotic complications.
  • Analysis of mechanisms contributing to hypercoagulability in DM.
  • Evaluation of evidence regarding the effectiveness of antithrombotic agents in diabetic patients.

Main Results:

  • DM is the leading cause of acquired thrombophilia due to endothelial damage, platelet dysfunction, altered clot structure, and glycation-related protein changes.
  • Evidence suggests reduced efficacy of thrombolytic drugs in diabetic patients.
  • The effect of acetylsalicylic acid (ASA) on thrombotic risk in DM requires further clarification.

Conclusions:

  • Diabetic thrombophilia is a multifactorial condition increasing thrombotic and cardiovascular risks.
  • Understanding these mechanisms is crucial for managing diabetic patients.
  • Further research is needed to optimize antithrombotic strategies, including ASA, in diabetes management.

Keywords:
coagulation factorsdiabetes mellitusdiabetic thrombophiliahypercoagulabilitythrombosis

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.7K

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
659
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
888
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.1K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K