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Updated: Feb 7, 2026

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Synthesis of 5-Methylene-2-pyrrolones
Marco Paolo Jacinto1, Patricio Pichling1, Marc M Greenberg1
1Department of Chemistry , Johns Hopkins University , 3400 North Charles Street , Baltimore , Maryland 21218 , United States.
Abstract:
A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.
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