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Updated: Feb 7, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K

miRNAs in bone metastasis

Douglas G Cheung1, Marta Buzzetti2, Gianpiero Di Leva2

  • 1a Department of Cancer Biology and Genetics , The Ohio State University , Columbus , Ohio , USA.

Expert Review of Endocrinology & Metabolism
|August 1, 2018
PubMed
Abstract

Insights

MicroRNAs (miRNAs) significantly impact bone metastasis by influencing pathways critical for bone health. These small RNAs offer potential as diagnostic biomarkers and therapeutic targets for bone metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Bone metastasis is a frequent complication of various primary cancers.
  • MicroRNAs (miRNAs) are key regulators of gene expression involved in bone homeostasis and cancer metastasis.
  • Dysregulation of miRNA pathways can promote bone metastasis by hijacking normal bone development processes.

Purpose of the Study:

  • To review signaling pathways in bone development and metastasis.
  • To discuss the role of miRNAs in cancer metastasis, specifically bone metastasis.
  • To highlight recent findings on miRNA involvement in bone metastasis.

Main Methods:

  • Literature search on PubMed using keywords 'miRNAs' and 'bone metastasis'.
  • Selection of relevant scientific articles published between 2010 and 2016.
  • Inclusion of seminal publications prior to 2010 regarding miRNA's metastatic role.

Main Results:

  • miRNAs play a significant role in regulating pathways essential for bone homeostasis.
  • miRNAs are implicated in the complex processes of cancer metastasis to bone.
  • Recent research highlights specific miRNA functions in bone metastasis formation.

Conclusions:

  • miRNAs are crucial regulators of bone homeostasis and bone metastasis.
  • The lack of effective diagnostic biomarkers and therapies for bone metastasis necessitates novel approaches.
  • miRNAs show promise as future diagnostic biomarkers and therapeutic targets for bone metastasis.
Keywords:
Micrornabone homeostasisbone metastasiscancernoncoding RNAs

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