Related Experiment Video
Updated: Feb 7, 2026
09:53
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
9.3K
An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study
L Krskova1, E Kabickova1, E Drahokoupilova1
1Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine and Faculty Hospital Motol, Charles University, Prague, Czech Republic
Neoplasma
|August 2, 2018
Summary
BCOR-CCNB3 positive sarcoma, a rare cancer similar to Ewing sarcoma, affects young males. Detecting BCOR-CCNB3 fusion transcripts in bone marrow indicates a high risk of tumor progression.
Area of Science:
- Oncology
- Molecular Genetics
- Pathology
Background:
- BCOR-CCNB3 positive sarcoma is a newly identified cancer in adolescents and young adults.
- It shares morphological and clinical similarities with Ewing sarcoma.
- The BCOR-CCNB3 fusion transcript arises from an X chromosome inversion.
Purpose of the Study:
- To analyze the morphological and molecular genetic features of BCOR-CCNB3 positive sarcomas.
- To investigate the clinical characteristics and outcomes of patients with this sarcoma type.
Main Methods:
- Morphological analysis of tumor samples.
- Molecular genetic analysis to detect the BCOR-CCNB3 fusion transcript.
- Clinical data review including patient demographics, diagnosis, and bone marrow involvement.
Main Results:
- Eight cases of BCOR-CCNB3 positive undifferentiated sarcoma were analyzed.
- Six of the eight patients were male, with a median age of 14 years.
- Bone marrow involvement was detected in 2 of 4 tested patients, suggesting high-risk progression.
Conclusions:
- BCOR-CCNB3 positive sarcoma predominantly affects young males.
- Detection of BCOR-CCNB3 fusion transcripts in bone marrow is a significant indicator of high-risk tumor progression.
- Further research is warranted to understand the biology and treatment of this rare sarcoma.
More Related Videos
05:30Surgical Approach and Complications of Stand-alone Lateral Trans-Psoas Interbody Fusion
Published on: February 14, 2025
1.6K
10:35A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
Published on: April 5, 2018
10.8K
Related Concept Videos
02:45Nuclear Fusion
33.9K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.9K
01:10Transcription
156.8K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
156.8K
02:16Transcription Factors
82.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
367
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
367
01:52Eukaryotic Transcription Inhibitors
11.0K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
02:42Eukaryotic Transcription Activators
12.8K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
12.8K