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Volumetric Analysis of Gallbladder in Extremely Premature Infants

Takashi Imamura1, Maki Sato1, Hayato Go1

  • 1Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Japan.

Journal of Medical Ultrasound
|August 2, 2018
PubMed

Insights

Gallbladder volume in extremely premature infants does not change significantly with serial measurements, even with enteral nutrition. This finding suggests stable gallbladder (GB) size during early infancy.

Area of Science:

  • Neonatology
  • Pediatric Gastroenterology
  • Medical Imaging

Background:

  • Extremely premature infants may experience physiological changes affecting organ development.
  • Gallbladder (GB) volume dynamics in this population are not well-characterized.
  • Serial changes in GB volume during early infancy warrant investigation.

Purpose of the Study:

  • To investigate serial changes in gallbladder (GB) volume in extremely premature infants.
  • To assess the relationship between GB volume and enteral nutrition.
  • To establish normative GB volume data for this vulnerable group.

Main Methods:

  • Prospective study of 30 extremely premature infants (gestational age 23-28 weeks).
  • Abdominal ultrasound used to measure GB volume between Day 0 and Day 56.
  • Gallbladder volume (mL)/weight (kg) (GV/W) calculated before enteral feeding.

Main Results:

  • GB detection rate decreased over time (93% Days 0-7 vs. <77% Days 10-56).
  • GV/W significantly decreased from admission (median 0.18) to <0.05 by Days 10-56.
  • No correlation found between GV/W and clinical variables.

Conclusions:

  • Gallbladder volume in extremely premature infants appears stable after initial measurements.
  • Enteral nutrition does not seem to significantly impact GB volume dynamics.
  • Further research may explore factors influencing GB visualization and volume in neonates.
Abstract

Keywords:
enteral feedingextremely premature infantsgallbladder volumeultrasonography

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