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Updated: Feb 7, 2026

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Published on: July 10, 2018

Rare Brain Tumor in a Neonate.

Shih-Huan Chen¹, Che-Sheng Ho^1,2, Nan-Chang Chiu^1,2

¹Department of Pediatric Neurology, MacKay Children's Hospital, Taipei, Taiwan.

Journal of Medical Ultrasound

|August 2, 2018

Summary

A rare neonatal brain tumor presented in a 17-day-old infant with an enlarged head. Pathological findings revealed an embryonal tumor characterized by multilayered rosettes, indicating a poor prognosis.

Keywords:

Brain tumors ETMR Neonate Ultrasonography

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Published on: May 31, 2020

Area of Science:

Pediatric Oncology
Neuro-oncology
Developmental Neuroscience

Background:

Neonatal brain tumors are exceptionally rare, often associated with poor clinical outcomes.
Early diagnosis and characterization are crucial for managing these aggressive pediatric neoplasms.

Observation:

A 17-day-old neonate presented with a rapidly increasing head circumference, a potential indicator of increased intracranial pressure.
Clinical examination revealed macrocephaly, prompting further investigation.

Findings:

Histopathological examination of the resected tumor confirmed the diagnosis of an embryonal tumor.
The tumor exhibited characteristic features of multilayered rosettes, suggesting a specific subtype of central nervous system embryonal neoplasm.

Implications:

This case highlights the importance of recognizing subtle clinical signs of neonatal brain tumors.
Understanding the specific pathological subtype is essential for guiding treatment strategies and predicting patient prognosis.
Further research into the molecular mechanisms of these rare tumors may lead to improved therapeutic interventions.