Ruthenium nanoparticle catalyzed selective reductive amination of imine with aldehyde to access tertiary amines
1School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. China. andonlee@163.com wyuchemsy@126.com.
Abstract:
Reductive amination is one of the most frequently used transformations in organic synthesis. Herein, we developed a novel ruthenium nanoparticle embedded ordered mesoporous carbon catalyst (Ru-OMC) and a new hydrosilylation process for the synthesis of tertiary amines. We present a direct reductive amination of imines (C[double bond, length as m-dash]N bond) with aldehydes (C[double bond, length as m-dash]O bond) using hydrosilane as the reducing reagent under mild conditions. Moreover, the Ru-OMC catalysts can be reused for up to 14 runs without noticeably losing activity.
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