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Ordering Single Cells and Single Embryos in 3D Confinement: A New Device for High Content Screening
Published on: September 18, 2016
Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells
Ru-Jia Yu1, Yi-Lun Ying1, Rui Gao1
1Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Abstract:
Nanopipettes provide a promising confined space that enables advances in electrochemical, optical, and mass spectrometric measurements at the nanoscale. They have been employed to reveal the hidden population properties and dynamics of single molecules and single particles. Moreover, new detection mechanisms based on nanopipettes have led to detailed information on single cells at high spatial and temporal resolution. In this Minireview, we focus on the fabrication and characterization of nanopipettes, summarize their wide applications for the analysis of single entities, and conclude with an outlook for advanced practical sensing.
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