Clinical utility of double-balloon enteroscopy in children: A single-centre experience in South China

Honglei Chen1, Yanan Liu1, Liping Fu1

  • 1Department of Gastrointestinal Endoscopy, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Insights

Double-balloon enteroscopy (DBE) is safe and effective for diagnosing and treating pediatric small bowel disorders. This study found DBE useful for indications like gastrointestinal bleeding and abdominal pain in children.

Area of Science:

  • Pediatric Gastroenterology
  • Endoscopic Procedures
  • Small Bowel Diseases

Background:

  • Double-balloon enteroscopy (DBE) is recognized for evaluating and treating small bowel conditions.
  • Clinical data on the use of DBE in pediatric populations are limited.
  • Understanding the indications, findings, and safety of pediatric DBE is crucial.

Purpose of the Study:

  • To investigate the clinical utility and safety of double-balloon enteroscopy (DBE) in children.
  • To identify common indications and findings associated with DBE in pediatric patients.
  • To assess the therapeutic potential and complication rate of DBE in this age group.

Main Methods:

  • Retrospective analysis of 72 double-balloon enteroscopy (DBE) procedures performed on 61 children (aged 6-14 years).
  • Procedures were conducted between April 2013 and December 2017.
  • Data collected included indications, findings, therapeutic interventions, and safety outcomes.

Main Results:

  • The most frequent indications for DBE were occult gastrointestinal bleeding and abdominal pain.
  • A high rate of abnormal findings (77.5%) was observed, with non-specific enteritis and Crohn's disease being common diagnoses.
  • Eight children benefited from therapeutic enteroscopy, and no serious complications were reported.

Conclusions:

  • Double-balloon enteroscopy (DBE) is a valuable diagnostic and therapeutic modality for pediatric small bowel disorders.
  • DBE demonstrates a favorable safety profile in children.
  • Further research can expand the application of DBE in pediatric gastroenterology.
Abstract

Related Concept Videos

Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.8K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

4.4K
What is an Experiment?01:12

What is an Experiment?

An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
18.9K
Thomson's e/m Experiment01:19

Thomson's e/m Experiment

In a beam of charged particles created by a heated cathode, the particles move at different speeds. However, many applications need a beam with uniform particle speeds. An arrangement known as a velocity selector uses electric and magnetic fields to pick particles with a particular speed from the beam.
A particle with charge q, speed v, and mass m enters an area from the top, where the magnetic and electric fields are perpendicular both to the particle's motion and to one another. The magnetic...
6.9K
Controls in Experiments01:13

Controls in Experiments

When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
17.7K
Randomized Experiments01:13

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
9.1K