Related Experiment Video
Updated: Feb 7, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Disproportionate Coupling Reaction of Sodium Sulfinates Mediated by BF3·OEt2: An Approach to
Liang Cao1, Shi-He Luo1,2, Kai Jiang1
1School of Chemistry and Environment , South China Normal University, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education , Guangzhou 510006 , P. R. China.
Abstract:
The BF3·OEt2-mediated disproportionate coupling reaction of sodium sulfinates was found for the first time. In this reaction, various S-S(O)2 bonds can be formed, efficiently giving thiosulfonates in moderate to excellent yields. As a convenient protocol for the synthesis of symmetrical and unsymmetrical thiosulfonates, its reaction mechanism involves the formation of a thiyl radical and sulfonyl radical via a sulfinyl radical disproportionation. What is more, this transformation can also be applied practically as a gram-scale reaction and to the two-step synthesis of sulfone and sulfonamide in one pot in situ using thiosulfonate as an intermediate.
More Related Videos
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Related Concept Videos
Coupled Reactions
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
Unsymmetric Bending
Symmetric Member in Bending
Deformations in a Symmetric Member in Bending
When the member is segmented into tiny cubic elements, it is observed that the primary stress...
Unsymmetric Loading of Thin-Walled Members
The concept of the shear center is crucial in countering the...
Beams with Unsymmetric Loadings
The first moment-area theorem determines the slope at any point on the beam. This theorem indicates that the change in slope between two points on a beam...