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A Direct Sensor to Measure Minute Liquid Flow Rates.

Preeti Sharma1, Jean-François Motte2, Frank Fournel3

  • 1Université Grenoble Alpes, CNRS, LIPhy , 38000 Grenoble , France.

Nano Letters
|August 3, 2018
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Summary

Researchers developed a novel method to measure minute liquid flow rates at the nanoscale. This technique utilizes a commercial pressure sensor to directly quantify flow in nanochannels, offering a versatile solution for nanofluidics research.

Keywords:
flow ratenanofluidicnanoporesensor

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Area of Science:

  • Nanofluidics
  • Fluid dynamics at the nanoscale

Background:

  • Flow rate measurement is critical in nanofluidics but experimentally challenging at the nanoscale.
  • Existing methods like particle tracking have limitations for direct, real-time measurement.

Purpose of the Study:

  • To develop a versatile and direct method for measuring minute flow rates in nanochannels.
  • To demonstrate a novel application of piezoresistive pressure sensors for nanofluidic flow sensing.

Main Methods:

  • Utilizing the compliant membrane of a commercial piezoresistive pressure sensor to accumulate liquid over time.
  • Directly measuring accumulated volume to determine flow rate.
  • Demonstrating the method with silicon oil flow in a 200 nm radius nanochannel.

Main Results:

  • Achieved reliable measurement of flow rates down to 1 pL/min.
  • The sensor is independent of liquid type, flow profile, and nanochannel characteristics.
  • Provided a direct voltage output, unlike indirect methods.

Conclusions:

  • The developed method offers a direct, versatile, and reliable approach for measuring nanofluidic flow rates.
  • The sensor's direct voltage output is suitable for real-time nanofluidic control applications.
  • This technique overcomes limitations of existing nanoscale flow measurement methods.