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Related Experiment Video

Updated: Feb 7, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Metabolic Syndrome, Thyroid Function and Autoimmunity - The PORMETS Study.

Luís Raposo1,2,3, Sandra Martins3,4,5, Daniela Ferreira6

  • 1Grupo de Estudo da Insulino-Resistência, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo, Lisboa, Portugal.

Endocrine, Metabolic & Immune Disorders Drug Targets
|August 3, 2018
PubMed
Summary
This summary is machine-generated.

High rates of undiagnosed thyroid dysfunction and autoimmunity were found in Portugal. Thyroid peroxidase antibodies were linked to lower metabolic syndrome risk, while free triiodothyronine levels were associated with increased risk.

Keywords:
Metabolic syndromecardiovascular diseasehyperthyroidismhypothyroidismportugalprevalencethyroid antibodiesthyroiditis.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Public Health

Background:

  • Thyroid dysfunction and autoimmunity prevalence in Portugal is unknown.
  • Metabolic syndrome is highly prevalent nationally.
  • The link between thyroid issues and cardiovascular risk requires clarification.

Purpose of the Study:

  • To determine the prevalence of thyroid dysfunction and autoimmunity in a national sample.
  • To investigate associations between thyroid markers and metabolic syndrome, its components, and other factors.

Main Methods:

  • A subsample of 486 adults from a national study was analyzed.
  • Data included questionnaires, physical measurements, and blood tests (TSH, FT4, FT3, antibodies, lipids, glucose, hs-CRP).

Main Results:

  • Prevalence: hypothyroidism (4.9%), hyperthyroidism (2.5%), undiagnosed dysfunction (72.2%). Antibody positivity: thyroid peroxidase (11.9%), thyroglobulin (15.0%).
  • Free triiodothyronine (FT3) showed a positive association with metabolic syndrome (OR: 2.019).
  • Thyroid peroxidase antibodies were negatively associated with metabolic syndrome (OR: 0.465) and triglycerides (OR: 0.321).

Conclusions:

  • Undiagnosed thyroid dysfunction and autoimmunity are prevalent in the Portuguese population.
  • Thyroid peroxidase antibodies are linked to a reduced risk of metabolic syndrome and lower triglycerides.
  • Elevated free triiodothyronine levels are associated with an increased risk of metabolic syndrome.