Related Experiment Video

Updated: Feb 7, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K

Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma

Shuai Sun1,2, Bowen Li1,2, Yufan Wang2

  • 1Peking University Shenzhen Hospital Clinical College, Anhui Medical University, Hefei, Anhui, China.

Disease Markers
|August 3, 2018
PubMed
Abstract

Insights

Circular RNAs (circRNAs) are downregulated in oral squamous cell carcinoma (OSCC). Hsa_circ_001242 may serve as a diagnostic biomarker for OSCC, showing potential for targeted treatment strategies.

Area of Science:

  • Molecular biology
  • Oncology
  • Biomarker discovery

Background:

  • Circular RNAs (circRNAs) are novel endogenous RNA structures with emerging roles in human cancers.
  • Limited research exists on circRNA function in oral squamous cell carcinoma (OSCC).

Purpose of the Study:

  • To investigate the expression of hsa_circ_001242 in OSCC.
  • To evaluate the diagnostic potential of hsa_circ_001242 in OSCC.

Main Methods:

  • Hsa_circ_001242 expression was quantified using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 40 paired OSCC tissues and four OSCC cell lines.
  • Diagnostic value was assessed using receiver operating characteristic (ROC) curve analysis.

Main Results:

  • Hsa_circ_001242 was significantly downregulated in OSCC tissues and cell lines compared to normal controls (P < 0.001).
  • Lower hsa_circ_001242 expression correlated with larger tumor size and advanced T stage (P < 0.05).
  • The ROC curve analysis yielded an area of 0.784, indicating diagnostic potential.

Conclusions:

  • Hsa_circ_001242 is significantly downregulated in OSCC.
  • Hsa_circ_001242 shows promise as a novel biomarker for OSCC diagnosis and potentially treatment.

More Related Videos

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma12:03

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

Published on: July 25, 2011

20.0K
Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

847

Related Concept Videos

Decreasing Function01:27

Decreasing Function

A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
299
Statistical Significance01:50

Statistical Significance

Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
22.0K
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
Decreased pulse rate01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
906
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Significance of Center of Mass01:12

Significance of Center of Mass

The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.7K