Retrospective study showed that blood sampling errors risked children's well-being and safety in a Swedish paediatric
Henrik Hjelmgren1,2, Anna Nilsson1,2, Nina Andersson-Papadogiannakis1,2
1Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Insights
Preanalytical errors (PAEs) in blood analysis are common in pediatric care, with clotting and insufficient filling being major issues. Overall quality control for pediatric blood sampling requires improvement.
Area of Science:
- Clinical Laboratory Science
- Pediatric Healthcare Quality
- Medical Diagnostics
Background:
- Preanalytical errors (PAEs) in blood analyses pose significant risks to patient safety.
- Effective quality indicators for blood sampling are crucial, especially in pediatric tertiary care.
Purpose of the Study:
- To investigate the frequency of PAEs in blood analyses.
- To assess the quality indicators of the blood sampling process in Swedish pediatric tertiary care.
Main Methods:
- Analysis of laboratory data from Astrid Lindgren Children's Hospital (2013-2014).
- Evaluation of preanalytical blood sampling performance using the Six Sigma scale.
- Calculation of defects per million (DPM) for error assessment.
Main Results:
- 5.4% of over 1.1 million analyses were rejected due to PAEs.
- PAEs varied significantly by hospital specialty (1.9-9.4%) and work shift.
- Clotting (51.3%) and incorrectly filled samples (25%) were the most common PAEs.
Conclusions:
- Frequent PAEs, particularly clotting and underfilling, impact pediatric blood sample quality.
- Error distribution varied across shifts and specific analyses.
- The overall quality control for pediatric blood sampling was deemed minimally acceptable.
Aim:
Blood analyses containing preanalytical errors (PAEs) are hazardous for patients. This study investigated the frequency of PAEs in blood analysis and the corresponding quality indicators of the sampling process in Swedish paediatric tertiary care.
Methods:
Data were retrieved from the laboratory at Astrid Lindgren Children's Hospital between 2013 and 2014. Preanalytical blood sampling performance was analysed according to the Six Sigma scale, ranging from 0 to 6 (933 137-3.4 defects per million [DPM]).
Results:
Of the 1 148 716 analyses, 61 656 (5.4%) were rejected due to PAEs. The PAEs ranged between hospital specialities from 1.9 to 9.4% (p < 0.001) and work shift times, from 6.0% in the day to 5.7% in the evening and 4.3% at night (p values <0.001). Clotting was the most prominent error (51.3%), affecting mostly haematology and coagulation analyses. Incorrectly filled samples represented almost 25% of all PAEs, with effects on chemistry, haematology and coagulation analyses. The sigma score for the overall preanalytical phase (3.2) corresponded to 44 565 DPM.
Conclusion:
Samples with PAEs were frequently clotted and insufficiently filled, and the distribution of errors varied within working shifts and specific analyses. The overall quality control in paediatric blood sampling was barely acceptable.
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