Related Experiment Video
Updated: Feb 7, 2026
23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
19.6K
Management of Multidrug-Resistant Tuberculosis
Charles L Daley1,2,3, Jose A Caminero4,5
1Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado.
Seminars in Respiratory and Critical Care Medicine
|August 3, 2018
Summary
Drug-resistant tuberculosis (TB) is a growing global health crisis. This review updates management strategies for multidrug-resistant TB (MDR-TB) and rifampin-resistant TB (RR-TB), including shorter regimens and new drugs.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Drug-resistant strains of Mycobacterium tuberculosis present a significant challenge to global tuberculosis control.
- Inappropriate treatment and transmission have led to alarming rates of drug-resistant tuberculosis, with an estimated 600,000 cases of multidrug-resistant tuberculosis (MDR-TB)/rifampin-resistant (RR) tuberculosis in 2016.
- Extensively drug-resistant strains have emerged in 123 countries, and only 22% of MDR-TB cases are currently receiving treatment.
Purpose of the Study:
- To review the current management of multidrug-resistant/rifampin-resistant tuberculosis (MDR/RR-TB).
- To provide updated recommendations on treatment strategies for MDR/RR-TB.
- To highlight the role of shorter course regimens and novel drugs in combating drug-resistant tuberculosis.
Main Methods:
- Literature review of existing studies and guidelines on MDR/RR-TB management.
- Analysis of World Health Organization (WHO) estimates and global surveillance data.
- Synthesis of current evidence on therapeutic interventions for drug-resistant tuberculosis.
Main Results:
- MDR-TB and RR-TB are significant global health concerns, affecting both new and retreatment tuberculosis cases.
- The emergence of extensively drug-resistant strains necessitates urgent attention and revised treatment approaches.
- Limited access to current MDR-TB therapy underscores the need for improved treatment accessibility and efficacy.
Conclusions:
- Effective management of MDR/RR-TB requires updated therapeutic strategies, including the judicious use of shorter regimens.
- The integration of new anti-tuberculosis drugs is crucial for improving treatment outcomes in patients with drug-resistant strains.
- Continued global efforts in surveillance, treatment, and prevention are essential to control the spread of drug-resistant tuberculosis.
More Related Videos
09:29In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
Published on: April 28, 2017
9.9K
07:35Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
13.3K
Related Concept Videos
01:29Pulmonary Tuberculosis I
985
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
985
01:28Pulmonary Tuberculosis II
1.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.5K
01:28Pulmonary Tuberculosis V
629
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
629
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
01:31Pulmonary Tuberculosis III
1.1K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.1K