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Related Experiment Video

Updated: Feb 7, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
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Published on: April 16, 2019

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Understanding and Treating Glioblastoma.

Wolfgang Wick1, Michael Platten2

  • 1Neurology Clinic, University of Heidelberg, INF 400, 69120 Heidelberg, Germany; Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Neurologic Clinics
|August 4, 2018
PubMed
Summary

Tumor-treating fields offer a new option for newly diagnosed patients, as traditional therapies have stalled. Precision medicine at progression requires analyzing recent tumor tissue for better treatment strategies.

Keywords:
BiomarkerGlioblastomaImmunotherapyMGMTPrecision medicineRadiomicsRepositioning of drugsTreatment resistance

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Area of Science:

  • Oncology
  • Medical Physics

Background:

  • Standard treatments for newly diagnosed patients have seen little advancement in ten years.
  • Previous concept-driven therapies, including anti-angiogenic and molecularly targeted drugs, have not succeeded in broad patient populations.
  • Tumor-treating fields (TTFields) represent a novel therapeutic modality.

Purpose of the Study:

  • To explore TTFields as a new treatment option for newly diagnosed patients.
  • To highlight the limitations of current precision medicine trials focusing on the newly diagnosed population.
  • To address the lack of established standards and the ineffectiveness of treatments at disease progression.

Main Methods:

  • Review of current treatment paradigms for newly diagnosed patients.
  • Analysis of the failure of 'all-comers' approaches in clinical trials.
  • Emphasis on the need for molecular precision and analysis of recent tumor tissue for patients at progression.

Main Results:

  • TTFields emerge as a promising alternative for newly diagnosed patients.
  • Current immunotherapy and molecularly targeted trials are primarily focused on the newly diagnosed population.
  • No standard treatment exists for patients at progression, with limited options beyond supportive care.

Conclusions:

  • Molecular precision approaches are crucial for treating patients at progression.
  • Recent tumor tissue analysis is essential for effective precision medicine at progression.
  • Future research should focus on targeted strategies rather than broad 'all-comers' approaches, especially at disease progression.