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A Preclinical Murine Model of Hepatic Metastases
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Brain Metastases.

Ayal A Aizer1, Eudocia Q Lee2

  • 1Department of Radiation Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Neurologic Clinics
|August 4, 2018
PubMed
Summary
This summary is machine-generated.

Treatments for brain metastases are evolving. Newer systemic therapies and advanced radiation techniques show promise for controlling both brain and body tumors, improving patient outcomes.

Keywords:
Brain metastasesBreast cancerLung cancerMelanomaStereotactic radiosurgeryWhole brain radiation

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Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Brain metastases significantly increase morbidity and mortality in solid tumor patients.
  • Current standard care involves local therapies like surgery and radiation.
  • Systemic therapies are gaining traction for comprehensive intracranial and extracranial disease control.

Purpose of the Study:

  • To review the latest data on local and systemic treatment options for brain metastases.
  • To highlight active research areas in radiation oncology for brain metastases.
  • To discuss emerging systemic therapies, including targeted agents and immunotherapies.

Main Methods:

  • Literature review of recent clinical trial data.
  • Focus on advancements in radiation therapy techniques.
  • Analysis of systemic therapies with improved central nervous system penetration.

Main Results:

  • Hippocampal sparing whole brain radiation therapy and stereotactic approaches are active research areas.
  • Newer targeted therapies show enhanced central nervous system penetration.
  • Immunotherapies demonstrate promising clinical trial results for brain metastases.

Conclusions:

  • Systemic therapies are increasingly important for managing brain metastases.
  • Advanced radiation techniques offer refined local control options.
  • Novel targeted and immunotherapies represent a promising frontier for brain metastases treatment.