Paraneoplastic Neurologic Syndromes
Myrna R Rosenfeld1, Josep Dalmau2
1Neuroimmunology, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Casanova 143, Barcelona, Spain 08036; Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19107, USA.
Abstract:
Paraneoplastic neurologic syndromes (PNS) are mostly immune-mediated disorders that occur in patients with cancer. Because the same neurologic syndromes may occur without a cancer association it is important to know the likelihood of PNS, which is based in part on the syndrome and the patient's demographics and risk factors for cancer. The presence of specific antineuronal antibodies can facilitate the diagnosis and suggest treatment strategies. Although some PNS are rarely responsive to therapies, other disorders are highly treatment responsive.
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