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Updated: Feb 7, 2026
06:55
Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP
Published on: February 14, 2022
2.2K
Pig lung transplant survival model.
Andrea Mariscal1,2,3, Lindsay Caldarone1,3, Jussi Tikkanen1,2
1Department of Thoracic Surgery, Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, Toronto, ON, Canada.
Nature Protocols
|August 4, 2018
Summary
This study details a swine lung transplant model to investigate primary graft dysfunction (PGD). The reliable 3-day survival model aids research into PGD development and therapeutic strategies post-lung transplantation.
Area of Science:
- Surgical techniques
- Animal models
- Transplantation immunology
Background:
- Primary graft dysfunction (PGD) is a major cause of mortality after lung transplantation.
- Ischemia reperfusion injury significantly contributes to PGD development.
- A reliable large animal model is crucial for translating PGD research to clinical practice.
Purpose of the Study:
- To describe a surgical protocol for swine lung transplantation.
- To establish a 3-day survival model in pigs post-lung transplant.
- To facilitate research on PGD development and therapeutic interventions.
Main Methods:
- Detailed surgical technique for swine lung transplantation.
- Postoperative management protocol for 3 days.
- Includes donor operation, transplant surgery, and postoperative care.
Main Results:
- A reliable pig lung transplant model was established.
- Recipients consistently survived for 3 days post-transplant.
- The model allows for PGD assessment and therapeutic testing.
Conclusions:
- The described swine lung transplant protocol reliably produces a 3-day survival model.
- This model is valuable for studying primary graft dysfunction.
- It serves as a platform for testing novel PGD therapies.
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