Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Molecules and Compounds

Molecules and Compounds

Atoms and Molecules

Labeling Emotion

Labeling Emotion

Emotional labeling is a cognitive process that involves identifying and naming one's emotions, such as anger, fear, happiness, or sadness. It allows individuals to recognize and express their internal emotional states, a critical aspect of emotional regulation and communication. Labeling emotions requires more than mere recognition; it also involves drawing upon memory and contextual cues to understand the current situation and apply a corresponding emotional label. For instance, feeling...

Types of Signaling Molecules

Types of Signaling Molecules

In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...

Positive Regulator Molecules

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single-atomic-ion detection with plasmon-enhanced whispering-gallery-mode microlasers.

Nature photonics·2026

Same author

Light-driven micro/nanobots.

Nanophotonics (Berlin, Germany)·2025

Same author

Association between hot spring residency and dry eye disease: a crossover gene-environment interaction (GxE) study in Taiwan.

Human genomics·2025

Same author

Monitoring Single DNA Docking Site Activity with Sequential Modes of an Optoplasmonic Whispering-Gallery Mode Biosensor.

Sensors (Basel, Switzerland)·2025

Same author

A formulation of combined <i>Poria cocos</i> and <i>Cordyceps militaris</i> rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

Journal of traditional and complementary medicine·2025

Same author

Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management.

Journal of biological engineering·2025

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Label-Free Optical Single-Molecule Micro- and Nanosensors.

Sivaraman Subramanian¹, Hsin-Yu Wu¹, Tom Constant¹

¹Living Systems Institute, Department of Physics and Astronomy, University of Exeter, Exeter, EX4 4QD, UK.

Advanced Materials (Deerfield Beach, Fla.)

|August 4, 2018

Summary

This summary is machine-generated.

Label-free optical nanosensors achieve unprecedented sensitivity for single-molecule detection. These advanced systems enable direct observation of dynamic molecular processes, opening new avenues in health and environmental monitoring.

Keywords:

Raman spectroscopy label-free optical detection nanosensors optical microcavity plasmonics quantum sensors single molecules

More Related Videos

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Published on: November 18, 2022

Related Experiment Videos

Last Updated: Feb 7, 2026

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Use of Dual Optical Tweezers and Microfluidics for Single-Molecule Studies

Published on: November 18, 2022

Area of Science:

Optics
Nanotechnology
Biophysics

Background:

Label-free optical sensor systems offer high sensitivity for micro/nanoscale detection.
Miniature optical devices are crucial for analyzing molecules in health, environmental, and security applications.
Current sensors approach single-molecule detection sensitivity.

Purpose of the Study:

To review recent advancements in label-free micro- and nanosensor techniques.
To summarize methods demonstrating single-molecule detection or sensitivity.
To highlight opportunities in the rapidly evolving field of single-molecule nanosensors.

Main Methods:

Utilizing micro- and nanosensors for light-matter interaction probing.
Employing quantum optical measurement techniques.
Focusing on label-free detection strategies.

Main Results:

Demonstration of extraordinary sensitivity in detecting physical, chemical, and biological entities.
Capability to observe dynamic processes at the single-molecule level directly with light.
Probing light-matter interactions over dynamic ranges often inaccessible by other optical techniques.

Conclusions:

Label-free micro- and nanosensors represent a significant breakthrough in molecular detection.
These sensors offer high sensitivity and enable direct observation of single-molecule dynamics.
The field holds immense potential for diverse scientific and technological applications.