Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diffusion01:12

Diffusion

219.9K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
219.9K
Electro-mechanical Systems01:19

Electro-mechanical Systems

1.7K
Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
1.7K
Scientific Laws and Theories02:31

Scientific Laws and Theories

89.0K
Scientific Laws
89.0K
Hess's Law03:40

Hess's Law

55.6K
There are two ways to determine the amount of heat involved in a chemical change: measure it experimentally, or calculate it from other experimentally determined enthalpy changes. Some reactions are difficult, if not impossible, to investigate and make accurate measurements for experimentally. And even when a reaction is not hard to perform or measure, it is convenient to be able to determine the heat involved in a reaction without having to perform an experiment.
55.6K
Concentration and Rate Law03:03

Concentration and Rate Law

39.4K
The rate of a reaction is affected by the concentrations of reactants. Rate laws (differential rate laws) or rate equations are mathematical expressions describing the relationship between the rate of a chemical reaction and the concentration of its reactants.
For example, in a generic reaction aA + bB ⟶ products, where a and b are stoichiometric coefficients, the rate law can be written as:
39.4K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

31.4K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the functional connectivity of astrocytic networks with AstroNet, a graph reconstruction algorithm coupled to image processing.

Communications biology·2025
Same author

Mapping general anesthesia states based on electro-encephalogram transition phases.

NeuroImage·2023
Same author

Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023
Same author

Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023
Same author

Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low MoCA Under Propofol Compared With Sevoflurane.

Anesthesia and analgesia·2023
Same author

How large the number of redundant copies should be to make a rare event probable.

Physical review. E·2023

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Unraveling the Initial Activation of the Adaptive Immune Response for Therapeutic Intervention
05:56

Author Spotlight: Unraveling the Initial Activation of the Adaptive Immune Response for Therapeutic Intervention

Published on: October 4, 2024

1.6K

Electrical transient laws in neuronal microdomains based on electro-diffusion.

J Cartailler1, D Holcman

  • 1Group of Computational Biology and Applied Mathematics, Ecole Normale Supérieure, 75005 Paris, France. david.holcman@ens.fr.

Physical Chemistry Chemical Physics : PCCP
|August 4, 2018
PubMed
Summary
This summary is machine-generated.

Researchers derived new current-voltage (I-V) laws for neuronal microdomains. These laws reveal deviations from Ohm's law and explain electrical conduction in dendritic spines, improving understanding of cellular electrical properties.

More Related Videos

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

11.9K
External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures
08:32

External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures

Published on: May 7, 2017

14.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Unraveling the Initial Activation of the Adaptive Immune Response for Therapeutic Intervention
05:56

Author Spotlight: Unraveling the Initial Activation of the Adaptive Immune Response for Therapeutic Intervention

Published on: October 4, 2024

1.6K
From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

11.9K
External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures
08:32

External Excitation of Neurons Using Electric and Magnetic Fields in One- and Two-dimensional Cultures

Published on: May 7, 2017

14.0K

Area of Science:

  • Neuroscience
  • Biophysics
  • Computational Biology

Background:

  • Cellular microdomains, like dendritic spines, are crucial for neuronal function, mediating communication and electrical signaling.
  • Characterizing the current-voltage (I-V) relationship in these nanoscale domains is vital but technically challenging due to size and voltage measurement limitations.

Purpose of the Study:

  • To develop novel analytical current-voltage (I-V) laws for neuronal microdomains.
  • To address the limitations of classical Ohm's law in describing electrical properties of small cellular structures.
  • To investigate the impact of geometry and ion channel distribution on electrical conduction.

Main Methods:

  • Derivation of analytical relations for I-V conversion considering varying ionic species.
  • Modeling of neuronal microdomains, specifically dendritic spines with constricted necks (hyperboloid shape).
  • Analysis of steady-state and transient current injections to study voltage distribution.

Main Results:

  • Demonstrated significant deviations from Ohm's law in neuronal microdomains.
  • Established that spine neck resistance alone is insufficient to define electrical properties.
  • Derived a new I-V law for constricted spine necks, highlighting the effect of narrow passages.
  • Showed that local voltage during transients depends on the spatial arrangement of voltage-gated channels.

Conclusions:

  • The developed electro-diffusion laws provide a framework for interpreting voltage distribution in neuronal microdomains.
  • These findings offer a more accurate biophysical model for understanding electrical signaling at the cellular level.
  • The study enhances our ability to analyze the complex electrical physiology of neuronal structures.