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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
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Cell-Like Micromotors.

Berta Esteban-Fernández de Ávila1, Weiwei Gao1, Emil Karshalev1

  • 1Department of NanoEngineering , University of California, San Diego , La Jolla , California 92093 , United States.

Accounts of Chemical Research
|August 4, 2018
PubMed
Summary
This summary is machine-generated.

Cell-like micromotors combine synthetic movement with biological functions for advanced in vivo applications. These biocompatible, cell-membrane-coated or cell-based machines offer enhanced capabilities for drug delivery and detoxification.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Micro- and nanosized machines are emerging as versatile agents for applications like detoxification and sensing.
  • Micromotors show promise in dynamic therapy, including drug delivery and microsurgery.
  • Practical in vivo use of synthetic micromotors requires biocompatible designs for complex biological fluids.

Purpose of the Study:

  • To highlight recent proof-of-concept examples of cell-like micromotors for in vivo tasks.
  • To discuss the design principles and actuation mechanisms of these biohybrid systems.
  • To explore the potential of cell-like micromotors in therapeutic and toxin-removing applications.

Main Methods:

  • Categorizing cell-like micromotors into cell membrane-coated and cell-based designs.
  • Reviewing various actuation mechanisms, including those utilizing natural cell motility.
  • Examining the integration of cellular components with synthetic micromachines.

Main Results:

  • Cell-like micromotors demonstrate efficient movement in complex biofluids like blood.
  • Biocompatibility of cell-derived materials minimizes immune response.
  • Incorporation of cellular functions enhances capabilities such as toxin binding and autonomous motion.

Conclusions:

  • Cell-like micromotors offer unique advantages for in vivo applications due to their biocompatibility and biomimetic functionalities.
  • These biohybrid systems represent a promising advancement for dynamic therapy and detoxification.
  • Further research is needed to address challenges for clinical translation and human trials.