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Updated: Feb 7, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Motor Neuron Disease: Pathophysiology, Diagnosis, and Management
Laura A Foster1, Mohammad Kian Salajegheh2
1Department of Medicine/Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston.
Abstract:
Patients with motor neuron diseases may present to primary care clinic or may be initially encountered in the inpatient setting. Timely diagnosis of these conditions is a key factor in early intervention and therapy, and accuracy of diagnosis is of extreme importance, in particular for amyotrophic lateral sclerosis with its poor prognosis. The aim of this review article is to provide a clinical and diagnostic framework for the diagnosis and evaluation of motor neuron disease for primary care physicians.
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