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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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Neuroprognostication for Patients with Amyotrophic Lateral Sclerosis: An Updated, Evidence-Based Review.

Christina Martin Schaff1, Jerome E Kurent2,3, Sherry Kolodziejczak4

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Seminars in Neurology
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PubMed
Summary

Prognosis in Amyotrophic Lateral Sclerosis (ALS) is complex. Factors like demographics, clinical features, and access to care influence patient survival and quality of life, enabling personalized care strategies.

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Area of Science:

  • Neurodegenerative Disorders
  • Neurology
  • Clinical Prognostics

Background:

  • Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease with variable presentation and progression.
  • Accurate prognostication in ALS is challenging due to disease heterogeneity.
  • Existing prognostic models often focus solely on survival time, neglecting quality of life.

Conclusions:

  • Understanding the impact of various factors on ALS progression is key to developing personalized prognostic strategies.
  • Integrating survivability and quality of life assessments enhances patient care.
  • Empowering patients through informed prognostication facilitates shared decision-making and goal achievement.