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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Eosinophilic esophagitis-Where are we today?
Cristina Targa Ferreira1, Mario Cesar Vieira2, Glenn T Furuta3
1Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Pediatria, Porto Alegre, RS, Brazil; Hospital Santo Antonio, Porto Alegre, RS, Brazil.
Jornal De Pediatria
|August 4, 2018
Summary
Eosinophilic esophagitis (EoE) is a growing condition diagnosed by symptoms and histology. Proton pump inhibitors are recommended as the initial treatment for pediatric patients.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Immunology
Background:
- Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease.
- Increasing incidence and prevalence over the past 2-3 decades.
- Diagnostic criteria are continually evolving.
Purpose of the Study:
- Provide an overview of diagnostic and therapeutic strategies for EoE.
- Increase pediatrician awareness of EoE.
- Summarize current management options for pediatric EoE.
Main Methods:
- Literature review of MEDLINE, Embase, and CINAHL databases.
- Analysis of recent consensus statements and guidelines.
Main Results:
- EoE diagnosis relies on symptoms and histology; other causes of eosinophilic inflammation must be excluded.
- Current management includes proton pump inhibitors (PPIs), dietary restrictions, topical steroids, and dilations.
- PPI-responsive esophageal eosinophilia and EoE are considered on a spectrum; PPIs are the first-line therapy.
Conclusions:
- EoE is a significant and evolving disease requiring further research.
- Understanding pathogenesis, risk factors, and natural history is crucial.
- Developing tailored diagnostic and therapeutic strategies is essential for patient care.
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