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Occupational Asthma From Epoxy Compounds.

Hille Suojalehto1, Joaquin Sastre2, Emilia Merimaa1

  • 1Finnish Institute of Occupational Health, Helsinki, Finland.

The Journal of Allergy and Clinical Immunology. in Practice
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PubMed
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Two-component epoxy resin systems and triglycidyl isocyanurate can cause occupational asthma in exposed workers. Detecting respiratory exposure to epoxy resin systems through air measurements is challenging.

Keywords:
CAS 2451-62-9CAS 25068-38-6CAS 9003-36-5ChemicalCoatingHardenerPainterPolyamineSensitizerTriglycidyl isocyanurate

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Area of Science:

  • Occupational Medicine
  • Toxicology
  • Pulmonology

Background:

  • Two-component epoxy resin systems (ERSs) are widely used in coatings.
  • Triglycidyl isocyanurate (TGIC) is found in polyester powder paints.
  • Epoxy compounds are known skin sensitizers, but respiratory effects are less understood.

Purpose of the Study:

  • To investigate occupational asthma (OA) in patients exposed to epoxy compounds.
  • To evaluate the respiratory-sensitizing potential of ERSs and TGIC.

Main Methods:

  • Retrospective review of 113 patients with work-related asthma symptoms.
  • Placebo-controlled specific inhalation challenge (SIC) with ERSs and TGIC.
  • Airborne polyamine and solvent vapor measurements in workplaces and during SIC.

Main Results:

  • Fifteen patients (13%) showed positive SIC reactions, confirming OA.
  • Late-type reactions were most common (12 cases).
  • Three patients had positive SIC reactions to TGIC; airborne polyamine levels were low.

Conclusions:

  • ERSs and TGIC can induce sensitizer-induced OA in some workers.
  • Diagnosing respiratory exposure to ERSs via air monitoring is difficult.