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Related Experiment Video

Updated: Feb 7, 2026

Basophil Activation Test for Allergy Diagnosis
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Sweat allergy.

Shunsuke Takahagi1, Akio Tanaka1, Michihiro Hide1

  • 1Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|August 5, 2018
PubMed
Summary
This summary is machine-generated.

Sweat allergy, linked to atopic dermatitis and cholinergic urticaria, involves a hypersensitivity to sweat components like MGL_1304 from Malassezia globosa. This fungal antigen triggers histamine release, offering targets for new treatments.

Keywords:
Atopic dermatitisCholinergic urticariaMGL_1304MalasseziaSweat

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Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • Sweat allergy is a type I hypersensitivity reaction to sweat contents.
  • It is prevalent in patients with atopic dermatitis (AD) and cholinergic urticaria (CholU).
  • A key allergen, MGL_1304, has been identified in sweat, produced by Malassezia globosa.

Purpose of the Study:

  • To investigate the role of MGL_1304 as a major sweat allergen.
  • To understand the mechanism of sweat allergy in AD and CholU patients.
  • To explore potential therapeutic strategies for sweat allergy.

Main Methods:

  • Intradermal skin tests and basophil histamine release assays were used.
  • Detection of MGL_1304-specific IgE in patient sera.
  • Analysis of cross-reactivity with other Malassezia species.

Main Results:

  • MGL_1304 induced significant histamine release from basophils of AD/CholU patients.
  • MGL_1304-specific IgE was detected in patient sera.
  • Cross-reactivity was observed with MGL_1304 homologs in other Malassezia species, but not human proteins.

Conclusions:

  • MGL_1304 is a major allergen in sweat allergy, particularly in AD and CholU.
  • Malassezia sensitization may occur through damaged skin barriers.
  • Targeting MGL_1304 and improving skin barrier function are potential therapeutic avenues.