Related Experiment Video
Updated: Feb 7, 2026
08:44
Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
12.8K
The interplay between exosomes and autophagy - partners in crime
Jing Xu1,2, Robert Camfield1, Sharon M Gorski3,2,4
1Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3.
Journal of Cell Science
|August 5, 2018
Summary
Exosome biogenesis and autophagy, key cellular processes, share molecular machinery and interact via the endolysosomal pathway. This interplay is crucial for cell homeostasis and implicated in neurodegeneration and cancer.
Area of Science:
- Cell Biology
- Molecular Biology
Background:
- The eukaryotic endomembrane system maintains cell homeostasis and responds to stress.
- Exosome biogenesis and autophagy are critical cellular processes linked by the endolysosomal pathway.
Purpose of the Study:
- To review the interplay between exosome biogenesis and autophagy.
- To highlight shared molecular machinery and crosstalk between these pathways.
- To discuss implications in neurodegeneration and cancer.
Main Methods:
- Literature review of exosome biogenesis and autophagy.
- Analysis of shared molecular mechanisms within the endolysosomal pathway.
- Examination of emerging roles of amphisomes.
Main Results:
- Exosome biogenesis and autophagy share molecular machinery and crosstalk.
- Autophagy-related proteins are involved in exosome biogenesis.
- Amphisomes play emerging roles in exosome-autophagy interactions.
Conclusions:
- The interplay between exosomes and autophagy is a significant area of cellular regulation.
- Understanding this crosstalk provides insights into neurodegenerative diseases and cancer pathogenesis.
Related Concept Videos
01:27Autophagy
5.9K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.9K
01:36Overview of Exosomes
3.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.7K
02:31Nuclear Export of mRNA
8.8K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.8K
03:34Theory of Romantic Attachment in Adulthood
50.0K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships.
50.0K
02:18Intrinsically Disordered Proteins
19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
01:10Nature and Nurture
22.4K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.4K