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Updated: Feb 7, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

Src and podoplanin forge a path to destruction.

Harini Krishnan¹, W Todd Miller¹, Francisco J Blanco²

¹Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA.

Drug Discovery Today

|August 6, 2018

Summary

This summary is machine-generated.

Src kinase and podoplanin receptor signaling drive tissue destruction in both cancer and arthritis. Targeting these pathways offers a promising strategy for developing novel therapeutics against these debilitating diseases.

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Last Updated: Feb 7, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

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Published on: June 12, 2011

Foraging Path-length Protocol for Drosophila melanogaster Larvae

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Published on: April 23, 2016

BioMEMS: Forging New Collaborations Between Biologists and Engineers

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Published on: November 1, 2007

Area of Science:

Oncology
Rheumatology
Molecular Biology

Background:

Cancer and arthritis are significant societal challenges with shared pathological pathways like inflammation and tissue degradation.
Current treatments for cancer and arthritis often cause adverse effects due to their impact on normal cell functions.

Purpose of the Study:

To elucidate specific pathways driving cancer and arthritis progression.
To explore the roles of Src kinase and podoplanin (PDPN) in promoting these diseases.
To identify Src and PDPN as potential therapeutic targets.

Main Methods:

Review of existing literature on cancer and arthritis pathogenesis.
Analysis of the roles of Src kinase and PDPN in cellular invasion and inflammation.
Identification of shared molecular targets.

Main Results:

Src kinase and PDPN are upregulated in various cells involved in cancer and arthritis.
Upregulation of Src and PDPN correlates with increased tissue invasion and inflammation.
These molecules represent common denominators in the progression of both diseases.

Conclusions:

Src kinase and PDPN are critical mediators of tissue destruction in cancer and arthritis.
Targeting the Src-PDPN axis presents a viable therapeutic strategy for co-treating cancer and arthritis.
Further research into these pathways could lead to more effective and targeted treatments.