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Src and podoplanin forge a path to destruction

Harini Krishnan1, W Todd Miller1, Francisco J Blanco2

  • 1Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY, USA.

Drug Discovery Today
|August 6, 2018
PubMed

Insights

Src kinase and podoplanin receptor signaling drive tissue destruction in both cancer and arthritis. Targeting these pathways offers a promising strategy for developing novel therapeutics against these debilitating diseases.

Area of Science:

  • Oncology
  • Rheumatology
  • Molecular Biology

Background:

  • Cancer and arthritis are significant societal challenges with shared pathological pathways like inflammation and tissue degradation.
  • Current treatments for cancer and arthritis often cause adverse effects due to their impact on normal cell functions.

Purpose of the Study:

  • To elucidate specific pathways driving cancer and arthritis progression.
  • To explore the roles of Src kinase and podoplanin (PDPN) in promoting these diseases.
  • To identify Src and PDPN as potential therapeutic targets.

Main Methods:

  • Review of existing literature on cancer and arthritis pathogenesis.
  • Analysis of the roles of Src kinase and PDPN in cellular invasion and inflammation.
  • Identification of shared molecular targets.

Main Results:

  • Src kinase and PDPN are upregulated in various cells involved in cancer and arthritis.
  • Upregulation of Src and PDPN correlates with increased tissue invasion and inflammation.
  • These molecules represent common denominators in the progression of both diseases.

Conclusions:

  • Src kinase and PDPN are critical mediators of tissue destruction in cancer and arthritis.
  • Targeting the Src-PDPN axis presents a viable therapeutic strategy for co-treating cancer and arthritis.
  • Further research into these pathways could lead to more effective and targeted treatments.

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