Related Experiment Video

Updated: Feb 7, 2026

Studying Normal Tissue Radiation Effects using Extracellular Matrix Hydrogels
11:01

Studying Normal Tissue Radiation Effects using Extracellular Matrix Hydrogels

Published on: July 24, 2019

6.3K

A Phase 1 Study of Nilotinib Plus Radiation in High-Risk Chordoma

Gregory M Cote1, Constance M Barysauskas2, Thomas F DeLaney3

  • 1Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts; Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts.

International Journal of Radiation Oncology, Biology, Physics
|August 6, 2018
PubMed
Abstract

Insights

Nilotinib combined with radiation therapy (RT) is safe for high-risk chordoma patients. Further research is needed to determine if this combination improves progression-free survival or overall survival compared to RT alone.

Area of Science:

  • Oncology
  • Medical Physics

Background:

  • Chordomas are rare, malignant tumors arising from notochordal remnants.
  • High-risk chordoma patients have poor progression-free survival and overall survival despite current treatments.
  • Platelet-derived growth factor receptor signaling is implicated in chordoma progression.

Purpose of the Study:

  • To determine the maximum tolerated dose (MTD), safety, and feasibility of nilotinib combined with radiation therapy (RT) in high-risk chordoma patients.
  • To evaluate nilotinib with RT as either a preoperative or definitive treatment modality.

Main Methods:

  • A phase 1 clinical trial was conducted with 23 patients diagnosed with high-risk, nonmetastatic chordoma.
  • Patients received nilotinib concurrently with RT (50.4 Gy RBE), followed by surgery and adjuvant RT, or definitive RT.
  • The MTD of nilotinib was established as 200 mg daily.

Main Results:

  • The MTD for nilotinib in combination with RT was determined to be 200 mg daily.
  • The objective best response rate was 6% (1 of 18 patients).
  • Median progression-free survival was 58.15 months, and median overall survival was 61.5 months, with a 2-year OS rate of 95%.

Conclusions:

  • Nilotinib 200 mg daily combined with RT is safe and well-tolerated in patients with high-risk chordoma.
  • Long-term follow-up is necessary to ascertain the impact of nilotinib plus RT on progression-free survival and overall survival.
  • The study provides a foundation for further investigation into targeted therapies for chordoma.

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.0K

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Phase Diagrams02:39

Phase Diagrams

A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.3K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
1.8K
Absorption of Radiation01:05

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.3K
Phase Transitions02:31

Phase Transitions

Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.2K