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Dishevelling Wnt and Hippo.
Nam Hee Kim1, Yoonmi Lee1, Jong In Yook2
1Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul 03722, Korea.
BMB Reports
|August 7, 2018
Summary
Dishevelled (DVL) mediates the nuclear export of phosphorylated YAP, linking the Wnt and Hippo pathways. Tumor suppressor loss co-activates YAP and Wnt, driving cancer progression.
Area of Science:
- Cellular Biology
- Molecular Biology
- Cancer Research
Background:
- Wnt and Hippo pathways are crucial for multicellular organism development and cellular functions.
- Dysregulation of these pathways is linked to human diseases, particularly cancer.
- YAP (Yes-associated protein) is a key transcription co-activator in the Hippo pathway, analogous to β-catenin in the Wnt pathway.
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