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Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy

Maria R Gualano1, Robin Thomas1, Renata Gili1

  • 1Department of Public Health, University of Turin, Turin, Italy.

Journal of Infection and Public Health
|August 7, 2018
PubMed

Insights

Universal infant rotavirus (RV) vaccination programs offer significant public health benefits and save money for healthcare systems. This strategy can reduce rotavirus gastroenteritis (RVGE) incidence and associated costs, making it a cost-effective public health intervention.

Area of Science:

  • Public Health
  • Vaccinology
  • Health Economics

Background:

  • Rotavirus-induced gastroenteritis (RVGE) is a leading cause of severe childhood illness requiring hospitalization.
  • Effective rotavirus (RV) vaccines are crucial for preventing severe RVGE and its complications.
  • Evaluating vaccination programs is essential for public health policy and resource allocation.

Purpose of the Study:

  • To assess the cost-effectiveness of a universal infant rotavirus (RV) vaccination program.
  • To analyze the budget impact of routine RV vaccination on a regional health service (RHS).
  • To inform the potential implementation of a national RV vaccination program in Italy.

Main Methods:

  • Cost-effectiveness analysis comparing a two-dose Rotarix vaccination schedule with no vaccination.
  • Budget impact analysis (BIA) to evaluate financial consequences for the Regional Health Service (RHS).

Main Results:

  • Universal RV vaccination is projected to yield significant public health benefits by reducing RVGE incidence.
  • The RHS can achieve substantial cost savings within a short timeframe due to decreased direct healthcare expenses for RVGE.
  • A universal vaccination program is estimated to save approximately €503,000 for the RHS over five years, with cost-savings observed from the second year.
  • The incremental cost-effectiveness ratio (ICER) was cost-saving at -€12,197/QALY for the RHS.

Conclusions:

  • Implementing a universal rotavirus vaccination strategy in the Piedmont Region can significantly control RVGE.
  • This preventive approach offers notable savings in economic and social resources for both the RHS and the general public.
  • The findings support the adoption of a national RV vaccination program to enhance child health and optimize healthcare spending.
Abstract

Keywords:
Burden of diseaseCost-effectivenessEconomic analysisRotavirusVaccine

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