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Related Concept Videos

Oxidation Numbers03:14

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Related Experiment Video

Updated: Feb 7, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
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Oxidative Stress from Environmental Exposures.

James M Samet1, Phillip A Wages2

  • 1Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27707.

Current Opinion in Toxicology
|August 7, 2018
PubMed
Summary
This summary is machine-generated.

Environmental pollutants cause oxidative stress, a key mechanism in toxicology. Redox toxicology investigates how xenobiotics disrupt cellular processes, with live-cell imaging aiding this research.

Keywords:
Oxidative stressenvironmental exposureglutathionelive cell imagingperoxiredoxinthiolsthioredoxintoxicologyxenobiotic

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Area of Science:

  • Environmental Toxicology
  • Redox Biology
  • Cellular Stress Response

Background:

  • Oxidative stress is a common toxicological mechanism for diverse environmental pollutants.
  • Redox toxicology is an emerging field investigating xenobiotic disruption of cellular redox balance.
  • Environmental contaminants can induce oxidative stress via direct, indirect, or metabolic pathway disruption.

Purpose of the Study:

  • To highlight oxidative stress as a unifying mechanism in environmental toxicology.
  • To underscore the significance of redox toxicology in understanding xenobiotic effects.
  • To emphasize the role of live-cell imaging in studying environmental oxidative stress.

Main Methods:

  • Review of existing literature on environmental pollutants and oxidative stress.
  • Focus on mechanisms of xenobiotic-induced oxidative stress.
  • Application of live-cell imaging techniques for real-time cellular analysis.

Main Results:

  • Environmental agents, including gases, organic compounds, particulates, and metal ions, commonly induce oxidative stress.
  • Xenobiotics can disrupt cellular thiol redox switches, impacting metabolic and bioenergetic processes.
  • Live-cell imaging provides a powerful tool to visualize and study cellular responses to environmental oxidative stress.

Conclusions:

  • Oxidative stress is a central pathway for the toxicity of many environmental agents.
  • Redox toxicology is crucial for understanding cellular responses to environmental contaminants.
  • Cells possess intrinsic defense systems to maintain redox homeostasis against environmental challenges.