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Updated: Feb 7, 2026

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Published on: May 29, 2021
Facile synthesis and efficient electrochemiluminescence of a readily accessible pyridopyrimidine
Ruizhong Zhang1, Feng Tong2, Liuqing Yang3
1Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, Wuhan, Hubei 430056, China. hongbo.wang@jhun.edu.cn and Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 5B7, Canada. zfding@uwo.ca.
Abstract:
Through a facile one-pot three-component reaction and a subsequent acetylation strategy, a novel greenish-blue fluorescent 4-imino-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile (IPPC) was synthesized. Electrochemiluminescence (ECL) of IPPC was firstly found to produce efficient emission at 500 nm with reducing coreactants. Its very similar ECL and PL spectra suggest that ECL production is mainly from the monomeric excited states.
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