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Related Experiment Video

Updated: Feb 7, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Progestogen for treating threatened miscarriage.

Hayfaa A Wahabi1, Amel A Fayed, Samia A Esmaeil

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Progesterone supplementation likely reduces miscarriage risk for threatened pregnancies. However, evidence suggests it may not significantly impact preterm birth rates or cause congenital abnormalities.

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Area of Science:

  • Reproductive Medicine
  • Obstetrics and Gynecology

Background:

  • Miscarriage, or spontaneous pregnancy loss before 20 weeks' gestation, is a common complication.
  • Progesterone is crucial for uterine receptivity and maintaining pregnancy; inadequate levels are linked to miscarriage.
  • Progesterone supplementation is a potential treatment for threatened miscarriage.

Purpose of the Study:

  • To evaluate the efficacy and safety of progestogens in treating threatened miscarriage.
  • To synthesize evidence from randomized controlled trials on progestogen use for threatened miscarriage.

Main Methods:

  • Systematic review and meta-analysis of randomized, quasi-randomized, or cluster-randomized controlled trials.
  • Searched multiple trial registries and databases up to August 2017.
  • Included seven trials with 696 participants, assessing outcomes using the GRADE tool.

Main Results:

  • Progestogen treatment likely reduces miscarriage risk (moderate-quality evidence).
  • Oral progestogens probably reduce miscarriage rates, while vaginal progesterone may have little to no effect (moderate-quality evidence).
  • Progestogens likely have little to no effect on preterm birth rates (low-quality evidence), and evidence on congenital abnormalities is uncertain (very-low quality evidence).

Conclusions:

  • Progestogens are likely effective in treating threatened miscarriage.
  • Evidence suggests progestogens do not significantly reduce preterm birth rates.
  • The effect of progestogens on congenital abnormalities remains uncertain due to limited evidence.