Independent Factors of Choroidal Thickness

We read with interest the article by Agarwal et al. reporting that mean choroidal thickness was significantly higher in HIV patients, especially those with HIV microangiopathy, compared to healthy controls matched for age, ethnicity, and gender. We would like to highlight two important factors which may affect choroidal thickness assessment, namely diurnal variation and myopia, which should be taken into consideration. It is important to know that mean choroidal thickness is likely to be higher among HIV patients, especially those with HIV microangiopathy, compared to healthy subjects. However, it is also important to note and account for other factors, such as timing of image acquisition and refractive errors of subjects, as these could potentially affect the study results.