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Perspectives on Neuroscience
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Future perspectives for cryptococcosis treatment.

Juliana Santos-Gandelman1, Márcio Lourenço Rodrigues2,3, Alice Machado Silva1,4

  • 1a Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas (INCT-IDN), Centro de Desenvolvimento Tecnológico em Saúde (CDTS) , Fundação Oswaldo Cruz (Fiocruz) , Rio de Janeiro/RJ , Brazil.

Expert Opinion on Therapeutic Patents
|August 8, 2018
PubMed
Summary

New treatments for cryptococcosis are urgently needed. Drug repurposing shows promise for developing novel anti-cryptococcal therapies due to high development costs and market failures.

Keywords:
Antifungalscryptococcosiscryptococcuspatent landscape

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Drug Development

Background:

  • Cryptococcosis is a severe fungal infection with limited treatment options.
  • No new antifungal drugs have been developed since 1990, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review technological advancements in cryptococcosis treatment disclosed in patent literature.
  • To identify compounds and molecules in development for cryptococcosis from 1995 to 2015.

Main Methods:

  • Patent literature search for cryptococcosis treatments (1995-2015).
  • Selection of compounds with in vivo activity or in company pipelines.
  • Supplementation with data from the Integrity database.

Main Results:

  • Drug development for cryptococcosis is fragmented and targets diverse molecular classes.
  • No single class of molecules dominates the development pipeline.
  • Development reflects the complexity of creating new anti-cryptococcal agents.

Conclusions:

  • Drug development for cryptococcosis faces significant challenges, including high costs and market failure.
  • Drug repurposing is identified as the most viable strategy for future cryptococcosis treatments.