Related Experiment Video
Updated: Feb 6, 2026
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Nanostructured Hyaluronic Acid-based Materials for the Delivery of siRNA
Keval Shah1, Sunita Chawla1, Anuradha Gadeval1
1National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, An Institute of National Importance, Government of India), Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat-382355, India.
Background:
The search for the effective treatment strategies to combat a disease that is characterized by abnormal cell growth and known as cancer is still required to reach its destiny. To address the problem, recently several gene therapies based on novel RNA interference (RNAi) have been proposed such as siRNA, micro RNA, shRNA, etc. out of which, siRNAs (silencing RNA) promises to show significant progress in pharmacotherapy, including considerable expansion of the druggable target space and the possibility of treating cancer.
Methods:
This review aims to uncover the hyaluronic acid (HA) and HA-hybridized nanoplatforms for siRNA delivery systems with a particular focus on the discussion of available reports while addressing the future potential of HA-based treatment strategies.
Results:
HA modified siRNA delivery, as promised, provided better targeting potential in many types of cancers. In addition, it was able to modify the release of siRNA as well. Toxicity of HA is well mentioned however, the loophole is yet to be filled by exploring various remedies for overcoming toxicity.
Conclusion:
To overcome the problems associated with these emerging genetic tools, investigators have employed glycosaminoglycan HA-based biopolymers. This biopolymer offers a variety of properties such as biodegradability, biocompatibility, aqueous solubility, viscoelasticity, and non-immunogenicity.
Insights
Hyaluronic acid (HA) enhances silencing RNA (siRNA) delivery for cancer treatment, improving targeting and release. Further research is needed to address HA
Area of Science:
- Biotechnology
- Nanomedicine
- Cancer Therapy
Background:
- Cancer treatment requires effective strategies against abnormal cell growth.
- Gene therapies, including RNA interference (RNAi) like siRNA, show promise for cancer pharmacotherapy.
- siRNA offers expanded druggable targets and potential for treating various cancers.
Purpose of the Study:
- To review hyaluronic acid (HA) and HA-hybridized nanoplatforms for siRNA delivery systems.
- To discuss current reports on HA-based siRNA delivery for cancer treatment.
- To address the future potential of HA-based treatment strategies.
Main Methods:
- Review of existing literature on HA and HA-hybridized nanoplatforms for siRNA delivery.
- Focus on studies demonstrating HA's role in modifying siRNA release and targeting.
- Exploration of HA's properties and potential remedies for toxicity.
Main Results:
- HA-modified siRNA delivery systems demonstrate enhanced targeting in various cancers.
- HA influences the release kinetics of siRNA.
- While HA exhibits favorable properties like biocompatibility, its toxicity requires further investigation and mitigation strategies.
Conclusions:
- Glycosaminoglycan HA-based biopolymers are employed to overcome challenges with genetic tools like siRNA.
- HA offers beneficial properties including biodegradability, biocompatibility, aqueous solubility, viscoelasticity, and non-immunogenicity.
- Further research is necessary to fully exploit HA's potential in siRNA delivery for cancer therapy while managing its toxicity.
Related Concept Videos
02:30siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
02:33Lewis Acids and Bases
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
02:54Ions as Acids and Bases
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
03:26Acids, Bases and Neutralization Reactions
02:58Bronsted-Lowry Acids and Bases
02:23Acid-Base Titration Curves
For a titration carried out for 25.00 mL of...