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Roux-en-Y Gastric Bypass Operation in Rats
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Scalable Gastric Resident Systems for Veterinary Application.

Alison Hayward1,2,3, Taylor Bensel1,2, Hormoz Mazdiyasni1,2

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A new scalable gastric resident dosage form platform offers prolonged drug retention in animals. This technology addresses species size variation, improving drug delivery and animal welfare across various settings.

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Area of Science:

  • Veterinary Pharmacology
  • Drug Delivery Systems
  • Animal Science

Background:

  • Gastric resident dosage forms improve drug delivery in farm animals but face challenges with species-specific body size variations.
  • Prolonged drug administration is crucial for effective treatment and improved animal welfare.

Purpose of the Study:

  • To investigate a scalable gastric resident dosage form platform for prolonged drug retention across different animal species.
  • To assess the adaptability of the dosage form for varied stomach dimensions and modulate drug release kinetics.

Main Methods:

  • Developed and tested prototype gastric resident dosage forms in rabbit and pig models.
  • Evaluated sustained gastric retention capabilities of the scalable platform.
  • Assessed the modulation of drug release kinetics using meloxicam as a model drug in pigs.

Main Results:

  • Demonstrated sustained gastric retention of the scalable dosage form in both rabbit and pig models.
  • Successfully modulated the release kinetics of meloxicam in pigs using the developed dosage form.
  • Confirmed the platform's scalability for different species.

Conclusions:

  • The scalable gastric resident dosage form platform enables prolonged drug retention and modulated release across species.
  • This technology has significant potential to improve animal welfare in research, agriculture, zoological, and clinical settings.
  • The platform offers a promising solution for consistent and effective drug delivery in veterinary medicine.