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Updated: Feb 6, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
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Critical microRNAs in Lung Cancer: Recent Advances and Potential Applications

Habib Zarredar1,2, Khalil Ansarin1, Behzad Baradaran3

  • 1Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran.

Anti-Cancer Agents in Medicinal Chemistry
|August 9, 2018
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are key regulators in lung cancer development. Manipulating miRNA expression using antagomiRs or mimics offers a promising therapeutic strategy for lung cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) regulate genes crucial for cell homeostasis and are implicated in human diseases, especially cancers.
  • Aberrant miRNA expression, including oncomiRs and tumor suppressors, drives tumorigenesis.
  • Lung cancer remains a leading cause of cancer mortality, with high mortality rates persisting despite treatment advances.

Purpose of the Study:

  • To review current knowledge on miRNA roles and targets in lung cancer.
  • To explore the potential of miRNAs as novel therapeutic agents for lung cancer.

Main Methods:

  • Comprehensive literature search of Scopus and PubMed databases.
  • Collection and summarization of research and review articles.
  • Keyword analysis focused on lung cancer target therapy, diagnostics, and prognostics.

Main Results:

  • Specific microRNAs are critical in lung cancer pathogenesis.
  • Modulating miRNA expression via antagomiRs or microRNA mimics shows therapeutic potential.
  • Targeting critical microRNAs can significantly impact lung cancer treatment.

Conclusions:

  • MicroRNA-based therapies, including knockdown or mimicking strategies, are effective when combined with chemotherapy.
  • These approaches hold significant promise for improving lung cancer treatment outcomes.
Keywords:
Lung cancermicroRNAoligonucleotidesoncomirtarget therapytumor suppressor microRNA.

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