Related Experiment Video
Updated: Feb 6, 2026
03:17
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
Published on: March 29, 2024
1.1K
Phenotyping normal kidney function in elderly patients with type 2 diabetes: a cross-sectional multicentre study
G P Fadini1, A Solini2, M L Manca3
1Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padua, Italy. gianpaolo.fadini@unipd.it.
Acta Diabetologica
|August 10, 2018
Summary
Older adults with type 2 diabetes (T2D) and preserved kidney function had lower BMI and triglycerides. This suggests reduced lipotoxicity may protect kidney health in long-standing T2D.
Area of Science:
- Nephrology
- Endocrinology
- Metabolic Diseases
Background:
- Type 2 diabetes (T2D) is a leading cause of chronic kidney disease (CKD).
- Kidney function decline is common in T2D, but some patients maintain normal function despite advanced age and disease duration.
- Understanding protective factors is crucial for preventing diabetic kidney disease.
Purpose of the Study:
- To phenotype elderly patients (≥80 years) with T2D and fully preserved kidney function.
- To identify factors associated with preserved kidney function in this specific population.
Main Methods:
- Analysis of a large Italian T2D outpatient cohort (n=281,217).
- Comparison of patients with preserved kidney function (eGFR >90 ml/min/1.73 m², AER <30 mg/24h) against those with mild impairment.
- Multivariable logistic regression adjusted for potential confounders.
Main Results:
- A subgroup of T2D patients aged ≥80 years (n=21,648) was analyzed.
- Fully preserved kidney function (G1A1) was found in 1.3% of aged T2D patients, with an average diabetes duration of 16 years.
- Lower Body Mass Index (BMI) and triglycerides were significantly associated with preserved kidney function (G1A1) compared to mild impairment (G2A1).
Conclusions:
- A subset of elderly patients with T2D maintains excellent kidney function.
- Lower BMI and triglyceride levels may indicate protection against lipotoxicity, preserving kidney function in long-standing T2D.
- Further research into lipotoxicity mechanisms could reveal novel therapeutic targets for diabetic kidney disease.
Related Concept Videos
01:50Cross-Sectional Research
12.7K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.7K
01:22Diabetes Mellitus: Type 2 and Gestational
5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
01:24Finding Volume Using Cross-Sectional Area
79
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
79
01:26Profile Leveling and Cross Sections
1.7K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.7K
01:16Spinal Cord: Cross-sectional Anatomy
4.9K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.9K
01:26Types of Functions I
313
Functions are fundamental mathematical tools that capture relationships between variables and describe how one quantity changes in relation to another. Their diverse forms allow them to model various real-world phenomena with precision and flexibility. Among the various categories, algebraic functions are prominent due to their formulation through basic arithmetic operations: addition, subtraction, multiplication, division, and root extraction.Algebraic functions include polynomial, rational,...
313