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Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives: with Relevance
Seetharaman Manojveer1, Saleh Salahi1,2, Ola F Wendt1
1Centre for Analysis and Synthesis, Department of Chemistry , Lund University , P.O. Box 124, SE-22100 Lund , Sweden.
Abstract:
A simple method has been developed for the cross dehydrogenative coupling between two different primary alcohols using readily available RuCl2(PPh3)3 as a precatalyst through the borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohol derivatives including long chain aliphatic alcohols and heteroaryl alcohols. In addition, the methodology was applied in a straightforward protocol to synthesize commercially available fragrances such as Rosaphen and Cyclamenaldehyde in good yields.
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