Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen
Xianwei Li1, Tianzhang Wang, Yu-Jing Lu
1School of Chemical Engineering and Light Industry, Guangdong University of Technology, No. 100 Waihuan Xi Road Guangzhou Higher Education Mega Center, Guangzhou, 510006, China. xwli@gdut.edu.cn luyj@gdut.edu.cn.
Abstract:
An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.
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