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Updated: Feb 6, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
12.0K
Vitamin E administration erases an enhanced oxidation in multiple sclerosis.
Jing-Zhi Guan1, Wei-Ping Guan2, Toyoki Maeda3
1a The 309th Hospital of Chinese People's Liberation Army, Beijing, China.
Canadian Journal of Physiology and Pharmacology
|August 10, 2018
Summary
Vitamin E (VE) may help multiple sclerosis (MS) patients by reducing harmful oxidation and maintaining telomere length (TL). This study suggests VE could be a beneficial supplement for managing MS progression.
Area of Science:
- Biomedical Science
- Neuroscience
- Oxidative Stress Research
Background:
- Systemic peroxidation is implicated in multiple sclerosis (MS) pathogenesis.
- Elevated oxidation correlates with serum lipid peroxidation and telomere length (TL) shortening in MS patients.
Purpose of the Study:
- To investigate the effect of vitamin E (VE) on peroxidation and clinical symptoms in MS patients.
- To analyze changes in serum lipid peroxidation and leukocyte telomere length (TL) following VE administration.
Main Methods:
- A study involving 34 MS patients receiving 400 mg/day of vitamin E (VE) for 3 months.
- Analysis of serum lipid peroxidation levels and telomere length (TL) in circulating leukocytes before and after VE treatment.
Main Results:
- MS patients exhibited elevated oxidation and shortened telomere length (TL).
- VE treatment significantly reduced serum lipid oxidation and maintained telomere length (TL).
Conclusions:
- Systemic peroxidation is linked to the development and progression of multiple sclerosis (MS).
- Vitamin E (VE), an antioxidant, shows potential as an effective supplementary therapeutic agent for MS.
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