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Relationship between Retinal Thickness Profiles and Visual Outcomes in Young Adults Born Extremely Preterm: The

Siva Balasubramanian1, Joanne Beckmann2, Hemal Mehta3

  • 1Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California; Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.

Ophthalmology
|August 10, 2018
PubMed

Insights

Young adults born extremely preterm have thicker retinal layers and reduced vision. Inner retinal layer thickness, particularly the ganglion cell layer, is linked to worse visual acuity, especially after ROP treatment.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Neuroscience

Background:

  • Extremely preterm birth can impact visual development.
  • Retinal layer thickness and visual function are key indicators of eye health.

Purpose of the Study:

  • To quantify inner and outer retinal layer thicknesses in young adults born extremely preterm (EP).
  • To understand the relationship between retinal layer thickness and visual function in this population.

Main Methods:

  • A prospective observational study followed 177 young adults (226 EP eyes, 128 control eyes) for 19 years.
  • Optical Coherence Tomography (OCT) was used to measure retinal layer thickness.
  • Best-corrected visual acuity (BCVA) was assessed and correlated with retinal measurements.

Main Results:

  • EP eyes showed significantly thicker inner and outer retinal layers and reduced BCVA compared to controls.
  • Inner retinal layer thickness, specifically the ganglion cell layer, correlated with worse BCVA.
  • Eyes treated for retinopathy of prematurity (ROP) had increased retinal thickness and poorer vision.

Conclusions:

  • Extremely preterm birth affects foveal maturation and long-term visual outcomes.
  • Increased ganglion cell layer thickness is an independent predictor of reduced visual acuity.
  • Neonatal ROP treatment is associated with worse visual acuity in early adulthood.
Abstract

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