Related Experiment Video

Updated: Feb 6, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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Clinical development of RET inhibitors in RET-rearranged non-small cell lung cancer: Update

Luis Mendoza1

  • 1IQVIA, Prague, Czech Republic.

Oncology Reviews
|August 11, 2018
PubMed

Insights

Precision oncology, standard for advanced non-small cell lung cancer (NSCLC), identifies actionable RET rearrangements. While current RET inhibitors show benefit, more potent drugs are needed for RET-associated NSCLC.

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Pharmacology

Background:

  • Precision oncology is the standard for advanced non-small cell lung cancer (NSCLC).
  • RET rearrangements are actionable driver oncogenes identified through molecular profiling.
  • Immunohistochemistry is insufficient for detecting RET alterations; FISH, RT-PCR, and NGS are complementary.

Purpose of the Study:

  • To review clinical data on RET inhibitors in RET-associated NSCLC.
  • To highlight the need for improved RET inhibitors.

Main Methods:

  • Review of clinical data on RET inhibitors.
  • Analysis of diagnostic tools for RET rearrangements.

Main Results:

  • Existing RET inhibitors (cabozantinib, vandetanib, lenvatinib) demonstrate clinical benefits in response and progression-free survival for NSCLC.
  • Clinical results with current RET inhibitors are not striking, indicating a need for enhanced therapies.

Conclusions:

  • RET rearrangements are important targets in NSCLC management.
  • Development of more selective and potent RET inhibitors is crucial for improving patient outcomes in RET-associated NSCLC.
Keywords:
Non-small cell lung cancerRET-rearrangementclinical trialsreviewtyrosine kinase

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