TOMMORROW neuropsychological battery: German language validation and normative study
Heather R Romero1,2, Andreas U Monsch3, Kathleen M Hayden1,2,4
1Joseph & Kathleen Bryan Alzheimer's Disease Research Center (Bryan ADRC), Duke University, Durham, NC, USA.
Alzheimer'S & Dementia (New York, N. Y.)
|August 11, 2018
Summary
This study validates the German TOMMORROW neuropsychological test battery for assessing preclinical Alzheimer's disease (AD). The German tests accurately identify cognitive changes, aiding diagnosis in German-speaking populations.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Gerontology
Background:
- Preclinical Alzheimer's disease (AD) assessment requires validated cognitive tests.
- Existing tools like the TOMMORROW battery are validated primarily in English-speaking regions.
- German-speaking populations need culturally equivalent cognitive assessments for accurate AD detection.
Purpose of the Study:
- To validate the German version of the TOMMORROW neuropsychological test battery.
- To establish normative data for German-speaking individuals.
- To assess the reliability and validity of cognitive measures for preclinical AD detection.
Main Methods:
- Recruited German-speaking healthy controls (NCs) and individuals with AD.
- Assessed construct validity, test-retest, and alternate form reliability in NCs.
- Examined criterion and discriminant validities using logistic and discriminant analyses.
- Compared cross-cultural equivalency with English versions.
Main Results:
- All German tests distinguished between NCs and AD patients.
- Episodic memory tests showed the highest discriminative power.
- Adequate test-retest and supported alternate form reliability for episodic memory.
- Age significantly predicted effect sizes, necessitating age-stratified normative data.
Conclusions:
- The German TOMMORROW test battery is reliable and valid for cognitive assessment.
- Performance is comparable to English versions, with regional variations noted.
- Provides crucial normative data for precise cognitive measurement and MCI diagnosis in German-speaking regions.
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