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Distributed fibre optofluidic laser for chip-scale arrayed biochemical sensing.

Chaoyang Gong1, Yuan Gong, Xuhao Zhao

  • 1Key Laboratory of Optical Fiber Sensing and Communications (Ministry of Education of China), University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave., Chengdu, 611731 China. ygong@uestc.edu.cn yjrao@uestc.edu.cn.

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Summary
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Distributed fibre optofluidic lasers (DFOFLs) enable high-throughput biochemical sensing by creating reproducible microcavities. This technology allows for sensitive, arrayed detection of analytes like horseradish peroxidase (HRP).

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Area of Science:

  • Optofluidics
  • Laser technology
  • Biochemical sensing

Background:

  • Optofluidic lasers (OFLs) offer high sensitivity for biochemical sensing.
  • A key limitation of OFLs for high-throughput applications is the lack of reproducible optical microcavities.

Purpose of the Study:

  • Introduce the distributed fibre optofluidic laser (DFOFL) concept.
  • Demonstrate DFOFL's potential for high-throughput sensing applications.
  • Address the challenge of reproducible microcavities in OFL-based sensing.

Main Methods:

  • Fabricate a one-dimensional (1D) DFOFL using precise fibre drawing of a hollow optical fibre (HOF).
  • Utilize DFOFL for arrayed colorimetric detection of enzymatic reactions, such as horseradish peroxidase (HRP) catalysis.
  • Experimentally demonstrate five-channel parallel detection with imaging capabilities.

Main Results:

  • Achieved a series of identical, uniformly distributed optical microcavities along the HOF.
  • Successfully monitored enzymatic reactions and detected HRP concentration using DFOFL.
  • Demonstrated parallel, multi-channel sensing and wavelength tunability over hundreds of nanometers.

Conclusions:

  • DFOFL technology overcomes the limitations of traditional OFLs for high-throughput sensing.
  • Spatial multiplexing of hundreds of channels is theoretically possible, significantly enhancing detection capacity.
  • Extending DFOFL to 2D chips via wavelength multiplexing offers further multi-functionality for advanced biochemical analysis.