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Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
Published on: August 23, 2024
Thorough characterization and stability of HP-β-cyclodextrin thymol inclusion complexes prepared by microwave
María Isabel Rodríguez-López1, María Teresa Mercader-Ros1, Santiago López-Miranda1
1Department of Food Technology and Nutrition, Molecular Recognition and Encapsulation Group (REM), UCAM Universidad Católica de Murcia, Murcia, Spain.
Background:
The aims of the present study were to obtain a stable dry powder formulation of cyclodextrins (CDs) encapsulating thymol, for successful use as an ingredient on an industrial scale, and to characterize the thymol-CDs complexes using different techniques.
Results:
Thymol was successfully solubilized in aqueous solutions and the Kc value increased with the pH of the media until the pH was neutral, giving the highest values (2583 ± 176 L mol-1 ) for HP-β-cyclodextrins (HP-β-CDs). The best encapsulation efficiency of thymol in solid complexes was obtained using the microwave (MWI) encapsulation method. The different characterization techniques have demonstrated the affinity of HP-β-CDs for thymol molecules, forming stable complexes.
Conclusions:
The results support the use of the MWI method in the preparation of solid HP-β-CD-thymol complexes, due to greater encapsulation efficiency and technological and economic advantages for industrial applications. © 2018 Society of Chemical Industry.
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