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Simultaneous infections with different enteric and respiratory tract viruses
Insights
Dual viral infections are common in young children. Rotavirus (RV) or adenovirus in stool frequently co-occurred with respiratory viruses like RSV, impacting patient health.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Public Health
Background:
- Gastroenteritis and respiratory infections are common in infants and young children.
- Rotavirus (RV) and adenovirus are significant causes of pediatric gastroenteritis.
- Respiratory viral pathogens are frequently detected in young children, often leading to significant morbidity.
Purpose of the Study:
- To investigate the prevalence of simultaneous respiratory viral infections in young children presenting with rotavirus (RV) or adenovirus gastroenteritis.
- To identify common respiratory viral pathogens co-infecting with RV or adenovirus.
- To determine the clinical significance of these dual infections in pediatric populations.
Main Methods:
- Prospective study of 484 infants and young children with confirmed rotavirus or adenovirus in stool samples.
- Respiratory samples were collected to test for the presence of common respiratory viral pathogens.
- Pathogen detection utilized methods such as PCR and antigen testing.
Main Results:
- Overall, 10.7% of study subjects exhibited dual infections (gastrointestinal and respiratory viruses).
- Among 385 RV-positive gastroenteritis patients, 8.3% had a concurrent respiratory viral infection.
- Respiratory syncytial virus (RSV) was identified in 34.1% of RV dual infections, and adenovirus was found in at least 40% of adenovirus gastroenteritis dual infections.
Conclusions:
- Dual viral infections involving gastrointestinal and respiratory pathogens are a significant concern in pediatric populations.
- The co-occurrence of rotavirus or adenovirus with respiratory viruses like RSV highlights the complex interplay of viral infections in young children.
- Further research is warranted to understand the clinical impact and management strategies for these dual infections.
Abstract:
Infants and young children with rotavirus (RV) or visualized adenovirus in their stools were tested for the simultaneous presence of a respiratory viral pathogen in their upper respiratory tract. Overall, at least 10.7% of 484 study subjects had such dual infections, including 8.3% of 385 RV-positive gastroenteritis patients and 24.3% of 37 RV-positive respiratory disease patients. Respiratory syncytial virus was present in 34.1% of 41 dual infections with RV and at least 40% of the 12 to 15 dual infections with visualized fecal adenovirus. Other pathogens found in the respiratory tract of patients with RV or visualized fecal adenovirus infections included influenza viruses, adenoviruses, parainfluenza viruses, rhinoviruses, and a cytomegalovirus.